The good and bad of adipose tissue macrophage exosomes in obesity.
Level V
Where this comes from
- Record sourced from PubMed, PMID 33826911.
- Also identified by DOI 10.1016/j.cmet.2021.03.011.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Adipose tissue macrophages regulate adipose tissue inflammation and systemic insulin-glucose homeostasis. In a recent study by Ying et al. (2021), M2 polarized bone marrow-derived macrophages secreted exosomes containing miR-690 that, when administered to obese mice, improved glucose-insulin homeostasis. miR-690 reduced expression of Nadk, which decreased inflammation and improved insulin signaling.
Medical subject headings
- Exosomes
- Insulin Resistance
- MicroRNAs