Pancreatic β cells put the glutamine engine in reverse.
Where this comes from
- Record sourced from PubMed, PMID 33826912.
- Also identified by DOI 10.1016/j.cmet.2021.03.010.
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Abstract
The metabolism of nutrients other than glucose influences insulin secretion by pancreatic β cells, but the mechanisms involved are incompletely understood. In this issue of Cell Metabolism, Zhang et al. (2020) report that reductive glutamine metabolism generates cytosolic NADPH to promote insulin secretion by β cells.
Medical subject headings
- Insulin-Secreting Cells