Sensitive protein alignments at tree-of-life scale using DIAMOND.
Where this comes from
- Record sourced from PubMed, PMID 33828273.
- Also identified by DOI 10.1038/s41592-021-01101-x and PMC identifier 8026399.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP.
Medical subject headings
- Computational Biology
- Proteins
- Sequence Alignment