Value of [⁶⁸Ga]Ga-FAPI-04 imaging in the diagnosis of renal fibrosis.

Abstract

Renal fibrosis is a pathological state in the progression of chronic kidney disease. Early detection and treatment are vital to prolonging patient survival. Renal puncture examination is the gold standard for renal fibrosis, but it has several limitations. This study aims to evaluate the diagnostic performance of a novel PET radiotracer, [⁶⁸Ga]Ga-fibroblast activation protein inhibitor (FAPI)-04, which specifically images fibroblast activation protein (FAP) expression for renal fibrosis. All patients underwent renal puncture before receiving [⁶⁸Ga]Ga-FAPI-04 PET/CT imaging. They then underwent [⁶⁸Ga]Ga-FAPI-04 PET/CT and immunochemistry examinations. The data obtained were analyzed. The [⁶⁸Ga]Ga-FAPI-04 PET/CT examination results demonstrated that almost all patients (12/13) exhibited increased radiotracer uptake. The maximum standardized uptake value (SUVmax) in patients with mild, moderate, and severe fibrosis was 3.92 ± 1.50, 5.98 ± 1.6, and 7.67 ± 2.23, respectively. Compared with renal puncture examination, non-invasive imaging of FAP expression through [⁶⁸Ga]Ga-FAPI-04 PET/CT quickly demonstrates bilateral kidney conditions with high sensitivity. [⁶⁸Ga]Ga-FAPI-04 PET/CT can facilitate the evaluation of disease progression, diagnosis, and the development of a treatment plan.