Comment on "Tumor-initiating cells establish an IL-33-TGF-β niche signaling loop to promote cancer progression".
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 33833094.
- Also identified by DOI 10.1126/science.abf2022.
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Abstract
Taniguchi <i>et al</i> (Research Articles, 17 July 2020, p. 269) claim that the cytokine interleukin-33 induces accumulation of tumor-associated macrophages expressing the immunoglobulin E receptor FcεRI. Although these findings hold great therapeutic promise, we provide evidence that the anti-FcεRI antibody used in this study is not specific for FcεRI on macrophages, which raises concerns about the validity of some of the conclusions.
Medical subject headings
- Interleukin-33
- Neoplasms