Response to Comment on "Tumor-initiating cells establish an IL-33-TGF-β niche signaling loop to promote cancer progression".
Where this comes from
- Record sourced from PubMed, PMID 33833096.
- Also identified by DOI 10.1126/science.abf3316.
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Abstract
Kamphuis <i>et al</i> argue that macrophages accumulated in the proximity of tumor-initiating cells do not express the high-affinity immunoglobulin E receptor FcεRIα. Although we cannot exclude the possibility of nonspecific binding of anti-FcεRIα antibody (clone MAR-1), we provide evidence that macrophages in squamous cell carcinomas express FcεRIα and that IL-33 induces FcεRIα expression in bone marrow cell-derived macrophages.
Medical subject headings
- Interleukin-33
- Neoplasms