Reactivation of Resolved Hepatitis B After Daratumumab for Multiple Myeloma.

Lee, Soon Kyu; Sung, Pil Soo; Park, Sung-Soo; Min, Chang-Ki; Nam, Heechul; Jang, Jeong Won; Choi, Jong Young; Yoon, Seung Kew · Clin Infect Dis · 2021

case_series · Level IV

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Abstract

The risk of reactivation of resolved hepatitis B virus (HBV) in hepatitis B surface antigen (HBsAg)-negative multiple myeloma patients after daratumumab has not been reported. Among 93 patients with daratumumab treatment, reactivation occurred in 6 patients (6.5%) with one hepatic failure. This is the first report demonstrating a considerable risk of reactivation of resolved HBV after daratumumab.

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