Prone position [¹⁸F]FDG PET/CT to reduce respiratory motion artefacts in the evaluation of lung nodules.

Abstract

2-Deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG) positron-emission tomography/computed tomography (PET/CT) is widely used to evaluate lung nodules, although respiratory motion artefacts may occur. We investigated the value of prone position PET/CT (pPET/CT) in lung nodule evaluation compared with standard supine position PET/CT (sPET/CT). We retrospectively reviewed 28 consecutive patients (20 men; age, 65.6 ± 12.1 years) with a lung nodule (size, 16.8 ± 5.5 mm) located below the sub-carinal level who underwent [¹⁸F]FDG PET/CT in a standard supine position and additional prone position. The maximum standardised uptake value (SUV_max), metabolic tumour volume (MTV), difference of diaphragm position between PET and CT (DDP), Dice's similarity coefficient (DSC) and occurrence of mis-registration were analysed. The [¹⁸F]FDG uptake of 20 biopsy-confirmed (15 malignant) nodules was evaluated visually. pPET/CT yielded a significantly higher SUV_max, lower MTV and shorter DDP than with sPET/CT (p = 0.043, 0.007 and 0.021, respectively). Mis-registration occurred in 53.6% of cases in sPET/CT and in 28.6% of cases in pPET/CT (p = 0.092). Among the 15 patients with mis-registration in sPET/CT, 10 patients (66.7%) did not show mis-registration in pPET/CT. DSC was higher in pPET/CT than in sPET/CT in 18 out of 28 patients (64.3%). In visual analysis, malignant nodules exhibited a higher [¹⁸F]FDG uptake positivity than benign nodules in pPET/CT (93.3% vs. 40.0%, p = 0.032) but not in sPET/CT (80.0% vs. 40.0%, p = 0.131). pPET/CT reduces respiratory motion artefact and enables more-precise measurements of PET parameters. • In prone position PET/CT, the decrease in the blurring effect caused by reduced respiratory motion resulted in a higher SUV_max and lower MTV in lung nodules than that with supine position PET/CT. • Prone position PET/CT was useful to interpret correctly malignant lung nodules as being positive in individual cases that had a negative result in supine position PET/CT.