Accuracy of Screening Tests for Celiac Disease in Asymptomatic Patients With Type 1 Diabetes.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 33852450.
- Also identified by DOI 10.14309/ajg.0000000000001193.
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Abstract
To evaluate the diagnostic performance of celiac serologic tests in asymptomatic patients with type 1 diabetes (T1D). Patients with T1D asymptomatic for celiac disease were prospectively screened with immunoglobulin A anti-tissue transglutaminase. Test characteristics were calculated and optimal cutoffs for a positive screen determined. Two thousand three hundred fifty-three patients were screened and 101 proceeded to biopsy. The positive predictive value of immunoglobulin A anti-tissue transglutaminase at the assay referenced upper limit of normal (30CU) was 85.9%, and the sensitivity and specificity were 100% and 38%, respectively. Thresholds extrapolated from the general population for the diagnostic evaluation of celiac disease are not suitable for use in asymptomatic T1D patients. Population-specific screening cutoffs are required.
Medical subject headings
- Asymptomatic Diseases
- Celiac Disease
- Diabetes Mellitus, Type 1