Response to Comment on "Circadian rhythms in the absence of the clock gene <i>Bmal1</i>".

Abstract

Abruzzi <i>et al</i> argue that transcriptome oscillations found in our study in the absence of <i>Bmal1</i> are of low amplitude, statistical significance, and consistency. However, their conclusions rely solely on a different statistical algorithm than we used. We provide statistical measures and additional analyses showing that our original analyses and observations are accurate. Further, we highlight independent lines of evidence indicating <i>Bmal1</i>-independent 24-hour molecular oscillations.