Comment on "Circadian rhythms in the absence of the clock gene <i>Bmal1</i>".
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 33859007.
- Also identified by DOI 10.1126/science.abe9230 and PMC identifier 9172996.
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Abstract
Ray <i>et al</i> (Reports, 14 February 2020, p. 800) report apparent transcriptional circadian rhythms in mouse tissues lacking the core clock component BMAL1. To better understand these surprising results, we reanalyzed the associated data. We were unable to reproduce the original findings, nor could we identify reliably cycling genes. We conclude that there is insufficient evidence to support circadian transcriptional rhythms in the absence of <i>Bmal1</i>.
Medical subject headings
- ARNTL Transcription Factors
- Circadian Rhythm