Neu(ronal) custodians of cutaneous immunity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33861962.
- Also identified by DOI 10.1016/j.cell.2021.03.040.
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Abstract
Sensory neurons have surfaced as key instigators of skin inflammation. In this issue of Cell, Zhang et al. define an anti-inflammatory Langerhans cell (LC)-neuron-mast cell (MC) circuit that underlies skin immune homeostasis. They uncover a role for LCs in maintaining innervation of MrgprD<sup>+</sup> nonpeptidergic neurons that restrain MC activation via glutamate secretion.
Medical subject headings
- Langerhans Cells
- Skin