Position preference of essential genes in prokaryotic operons.
basic_science · Level V
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- Record sourced from PubMed, PMID 33886641.
- Also identified by DOI 10.1371/journal.pone.0250380 and PMC identifier 8061932.
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Abstract
Essential genes, which form the basis of life activities, are crucial for the survival of organisms. Essential genes tend to be located in operons, but how they are distributed in operons is still unclear for most prokaryotes. In order to clarify the general rule of position preference of essential genes in operons, an index of the average position of genes in an operon was proposed, and the distributions of essential and non-essential genes in operons in 51 bacterial genomes and two archaeal genomes were analyzed based on this new index. Consequently, essential genes were found to preferentially occupy the front positions of the operons, which tend to be expressed at higher levels.
Medical subject headings
- Archaea
- Bacteria
- Genes, Archaeal
- Genes, Bacterial
- Operon