Novel recessive locus for body mass index in childhood asthma.
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- Record sourced from PubMed, PMID 33888571.
- Also identified by DOI 10.1136/thoraxjnl-2020-215742 and PMC identifier 8531156.
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Abstract
Most genome-wide association studies of obesity and body mass index (BMI) have so far assumed an additive mode of inheritance in their analysis, although association testing supports a recessive effect for some of the established loci, for example, rs1421085 in <i>FTO</i> In two whole-genome sequencing (WGS) studies of children with asthma and their parents (892 Costa Rican trios and 286 North American trios), we discovered an association between a locus (rs9292139) in <i>LOC102724122</i> and BMI that reaches genome-wide significance under a recessive model in the combined analysis. As the association does not achieve significance under an additive model, our finding illustrates the benefits of the recessive model in WGS analyses.
Medical subject headings
- Asthma
- Genome-Wide Association Study