Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident.
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- Record sourced from PubMed, PMID 33888599.
- Also identified by DOI 10.1126/science.abg2538 and PMC identifier 9022889.
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Abstract
The 1986 Chernobyl nuclear power plant accident increased papillary thyroid carcinoma (PTC) incidence in surrounding regions, particularly for radioactive iodine (<sup>131</sup>I)-exposed children. We analyzed genomic, transcriptomic, and epigenomic characteristics of 440 PTCs from Ukraine (from 359 individuals with estimated childhood <sup>131</sup>I exposure and 81 unexposed children born after 1986). PTCs displayed radiation dose-dependent enrichment of fusion drivers, nearly all in the mitogen-activated protein kinase pathway, and increases in small deletions and simple/balanced structural variants that were clonal and bore hallmarks of nonhomologous end-joining repair. Radiation-related genomic alterations were more pronounced for individuals who were younger at exposure. Transcriptomic and epigenomic features were strongly associated with driver events but not radiation dose. Our results point to DNA double-strand breaks as early carcinogenic events that subsequently enable PTC growth after environmental radiation exposure.
Medical subject headings
- Chernobyl Nuclear Accident
- Mutation
- Neoplasms, Radiation-Induced
- Thyroid Cancer, Papillary
- Thyroid Neoplasms