My, oh, MYO9A! Just how complex can regulation of the podocyte actin cytoskeleton get?
Where this comes from
- Record sourced from PubMed, PMID 33892856.
- Also identified by DOI 10.1016/j.kint.2021.01.006.
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Abstract
Genetics contributes significantly to the development of kidney diseases. In the case of glomerular diseases such as focal segmental glomerulosclerosis, over a dozen genes involved in maintaining and regulating the actin cytoskeleton of podocytes have been implicated. A new study adds the atypical myosin, MYO9A, to that list using a combination of human and mouse genetics, suggesting a link to enhanced RhoA activity. Unraveling the growing web of actin regulators remains a key challenge to understanding podocytopathies.
Medical subject headings
- Glomerulosclerosis, Focal Segmental
- Podocytes