Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 33899032.
- Also identified by DOI 10.1016/j.xcrm.2021.100269 and PMC identifier 8055165.
- Licence recorded as CC BY-NC-ND.
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Abstract
Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al. describe the role of soluble interleukin-6 receptor (sIL-6R) in IL-6 <i>trans</i>-signaling and how understanding the IL-6:sIL-6R axis might help define and treat COVID-19 cytokine storm syndrome.
Medical subject headings
- COVID-19
- Cytokine Release Syndrome
- Receptors, Interleukin-6