TIMEx: tumor-immune microenvironment deconvolution web-portal for bulk transcriptomics using pan-cancer scRNA-seq signatures.
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- Record sourced from PubMed, PMID 33901274.
- Also identified by DOI 10.1093/bioinformatics/btab244 and PMC identifier 11025676.
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Abstract
The heterogeneous cell types of the tumor-immune microenvironment (TIME) play key roles in determining cancer progression, metastasis and response to treatment. We report the development of TIMEx, a novel TIME deconvolution method emphasizing on estimating infiltrating immune cells for bulk transcriptomics using pan-cancer single-cell RNA-seq signatures. We also implemented a comprehensive, user-friendly web-portal for users to evaluate TIMEx and other deconvolution methods with bulk transcriptomic profiles. TIMEx web-portal is freely accessible at http://timex.moffitt.org. Supplementary data are available at Bioinformatics online.