Outcomes of curative-intent radiotherapy in non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD).

Tang, Celion; Mistry, Hitesh; Bayman, Neil; Chan, Clara; Cobben, David; Faivre-Finn, Corinne; Harris, Margaret; Kennedy, Jason et al. · Radiother Oncol · 2021

retrospective_cohort · Level III

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Abstract

Outcomes of non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD n = 587) and interstitial lung disease (ILD n = 34) treated with curative-intent radiotherapy were retrospectively investigated. Presence of ILD but not decreased forced expiratory volume in 1-second correlated with poor overall survival. Increased breathlessness and oxygen requirements after radiotherapy were observed in severe/very severe COPD and ILD.

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