Here to stay: Writing lasting epigenetic memories.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 33930295.
- Also identified by DOI 10.1016/j.cell.2021.04.007.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this issue of Cell, Nuñez et al. develop CRISPRoff, a programmable epigenetic memory writer capable of establishing specific gene silencing programs that are stably maintained across cell division and differentiation. The singular dCas9 fusion offers a simple, reliable, and general tool for genome-wide screens, multiplexed editing, and potential therapeutics.
Medical subject headings
- CRISPR-Cas Systems
- Gene Editing