Computational investigation of platelet thrombus mechanics and stability in stenotic channels.

Abstract

The stability of a platelet thrombus under flow is believed to depend strongly on the local hemodynamics and on the thrombus' porosity, permeability, and elasticity. A two-phase continuum model is used to investigate the biomechanics of thrombus stability in stenotic channels. It treats the thrombus as a porous, viscoelastic material moving differently than the background fluid. The dynamic clot-flow interaction is modeled through a frictional drag term. The model explicitly tracks the formation and breaking of interplatelet molecular bonds, which directly determine the viscoelastic property of the thrombus and govern its ability to resist fluid drag. We characterize the stability/fragility of thrombi for various flow speeds, porosities, bond concentrations, and bond types.