Sex differences in fear memory consolidation via Tac2 signaling in mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33941789.
- Also identified by DOI 10.1038/s41467-021-22911-9 and PMC identifier 8093426.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Memory formation is key for brain functioning. Uncovering the memory mechanisms is helping us to better understand neural processes in health and disease. Moreover, more specific treatments for fear-related disorders such as posttraumatic stress disorder and phobias may help to decrease their negative impact on mental health. In this line, the Tachykinin 2 (Tac2) pathway in the central amygdala (CeA) has been shown to be sufficient and necessary for the modulation of fear memory consolidation. CeA-Tac2 antagonism and its pharmacogenetic temporal inhibition impair fear memory in male mice. Surprisingly, we demonstrate here the opposite effect of Tac2 blockade on enhancing fear memory consolidation in females. Furthermore, we show that CeA-testosterone in males, CeA-estradiol in females and Akt/GSK3β/β-Catenin signaling both mediate the opposite-sex differential Tac2 pathway regulation of fear memory.
Medical subject headings
- Central Amygdaloid Nucleus
- Conditioning, Classical
- Fear
- Memory Consolidation
- Protein Precursors
- Tachykinins