Hypoxia-inducible CAR expression: An answer to the on-target/off-tumor dilemma?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 33948575.
- Also identified by DOI 10.1016/j.xcrm.2021.100244 and PMC identifier 8080122.
- Licence recorded as CC BY-NC-ND.
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Abstract
On-target/off-tumor toxicity is one of the major concerns regarding CAR T-cell therapy. Kosti et al.<sup>1</sup> demonstrate that this form of toxicity can be prevented by designing a CAR whose expression is controlled by oxygen levels in the tumor environment.
Medical subject headings
- Hypoxia
- Immunotherapy, Adoptive