Immunotherapy breaches low-sugar dieting of tumor Treg cells.
Level V
Where this comes from
- Record sourced from PubMed, PMID 33951469.
- Also identified by DOI 10.1016/j.cmet.2021.04.010.
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Abstract
Glycolysis supports effector T cell function but is detrimental to the immunosuppressive activity of regulatory T cells. In a recent issue of Nature, two papers address a role for glucose and lactate availability within the tumor microenvironment for the balance of pro- and anti-tumoral effects of T cells and the efficacy of neoadjuvant cancer immunotherapy.
Medical subject headings
- Neoplasms
- T-Lymphocytes, Regulatory