Mitochondria ensure immune surveillance by retro-communication with the nucleus.
Where this comes from
- Record sourced from PubMed, PMID 33951470.
- Also identified by DOI 10.1016/j.cmet.2021.04.013.
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Abstract
Mitochondria cover several functions within the cell, including an influence on the transcription of nuclear genes. Recent work by Tigano et al. (2021) in Nature has identified a pathway of mitochondrial retrograde communication in which the nucleus senses aberrations in the mtDNA to drive the innate immune response.
Medical subject headings
- Cell Nucleus
- Mitochondria