Midlobular zone 2 hepatocytes: A gatekeeper of liver homeostasis.
Level V
Where this comes from
- Record sourced from PubMed, PMID 33951471.
- Also identified by DOI 10.1016/j.cmet.2021.04.005.
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Abstract
The liver consists of different zones that vary in function depending on their lobular localization. It remained unclear which zone serves as a source of repopulating/regenerating hepatocytes; however, experiments by Wei et al. (2021) in 11 CreER knockin murine strains revealed a vital role for zone 2 hepatocytes in liver homeostasis.
Medical subject headings
- Hepatocytes
- Liver Regeneration