Effects of Central Obesity on Esophageal Epithelial Barrier Function.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 33955725.
- Also identified by DOI 10.14309/ajg.0000000000001196 and PMC identifier 8243777.
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Abstract
We assessed if obesity perturbs the esophageal epithelial barrier function independent of promotion of gastroesophageal reflux (GER). Thirty-eight participants were divided into 4 groups: Obesity-/GER-, Obesity+/GER-, Obesity-/GER+, and Obesity+/GER+. Esophageal intercellular space and desmosome density (structural integrity) and fluorescein leak (functional integrity) were measured. The Obesity+/GER- group demonstrated increased intercellular space, reduced desmosome density, and increased fluorescein leak compared with control subjects. These changes were similar but not additive to findings seen in Obesity-/GER + and Obesity+/GER+ patients. Central obesity impairs structural and functional integrity of the esophageal barrier independent of GER, likely predisposing to esophageal injury.
Medical subject headings
- Esophageal Mucosa
- Extracellular Space
- Gastroesophageal Reflux
- Obesity, Abdominal
- Permeability