Progressive and Parallel Decline of Humoral and T-Cell Immunity in Convalescent Healthcare Workers with Asymptomatic or Mild-to-Moderate Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 33961690.
- Also identified by DOI 10.1093/infdis/jiab242 and PMC identifier 8136002.
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Abstract
We investigated the duration of humoral and T-cell immune response in paired samples among 22 convalescent healthcare workers (HCWs). A median of 1.8 months after diagnosis, T-cell response was significantly lower in HCWs with early loss of antibodies (6 cases [27%]). After 5.1 months, antibody decline was observed in 77% of cases (41% seroreverted; P < .01), and 36% had lost T-cell response (75% lost response to spike protein). Persistence of immune response was observed in those who developed a greater adaptive immune response. Our data point to the initial immune response as the relevant player in coronavirus disease 2019 duration of protection.
Medical subject headings
- COVID-19
- Convalescence
- Health Personnel
- Immunity, Humoral
- T-Lymphocytes