Overcoming translational barriers in modeling macular degenerations.
basic_science · Level V
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- Record sourced from PubMed, PMID 33961756.
- Also identified by DOI 10.1016/j.stem.2021.04.015.
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Abstract
Advances in tissue mimetics are paving the way for interrogating both the pathobiology of human disease and innovative therapeutic paradigms. In this issue of Cell Stem Cell, Manian et al. (2021) develop a novel iPSC-derived retinal pigment epithelium (RPE)-choriocapillaris (CC) complex that recapitulates key features of macular degenerations.