Neutrophil elastase: Nonsense lost in translation.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 33961760.
- Also identified by DOI 10.1016/j.stem.2021.04.007.
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Abstract
In this issue of Cell Stem Cell, Daniel Bauer and colleagues investigate the pathogenesis of ELANE-associated severe congenital neutropenia (SCN) and describe two potentially universal gene correction strategies for autosomal dominant disorders (Rao et al., 2021). One exploits nonsense-mediated decay to prevent translation of the mutant allele. The other unexpectedly blocks translation by shortening the 3'-UTR.
Medical subject headings
- Leukocyte Elastase
- Neutropenia