Emerging concepts in intestinal immune control of obesity-related metabolic disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 33972511.
- Also identified by DOI 10.1038/s41467-021-22727-7 and PMC identifier 8110751.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The intestinal immune system is an important modulator of glucose homeostasis and obesity-associated insulin resistance. Dietary factors, the intestinal microbiota and their metabolites shape intestinal immunity during obesity. The intestinal immune system in turn affects processes such as intestinal permeability, immune cell trafficking, and intestinal hormone availability, impacting systemic insulin resistance. Understanding these pathways might identify mechanisms underlying treatments for insulin resistance, such as metformin and bariatric surgery, or aid in developing new therapies and vaccination approaches. Here, we highlight evolving concepts centered on intestinal immunity, diet, and the microbiota to provide a working model of obesity-related metabolic disease.
Medical subject headings
- Gastrointestinal Microbiome
- Metabolic Diseases
- Obesity