Ultra-high-performance liquid chromatography high-resolution mass spectrometry variants for metabolomics research.
review · Level V
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- Record sourced from PubMed, PMID 33972782.
- Also identified by DOI 10.1038/s41592-021-01116-4.
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Abstract
Ultra-high-performance liquid chromatography high-resolution mass spectrometry (UHPLC-HRMS) variants currently represent the best tools to tackle the challenges of complexity and lack of comprehensive coverage of the metabolome. UHPLC offers flexible and efficient separation coupled with high-sensitivity detection via HRMS, allowing for the detection and identification of a broad range of metabolites. Here we discuss current common strategies for UHPLC-HRMS-based metabolomics, with a focus on expanding metabolome coverage.
Medical subject headings
- Chromatography, High Pressure Liquid
- Mass Spectrometry
- Metabolomics