Reduced microglia activity in patients with long-term immunosuppressive therapy after liver transplantation.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 33978829.
- Also identified by DOI 10.1007/s00259-021-05398-w and PMC identifier 8712291.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Calcineurin inhibitors (CNI) can cause long-term impairment of brain function. Possible pathomechanisms include alterations of the cerebral immune system. This study used positron emission tomography (PET) imaging with the translocator protein (TSPO) ligand <sup>18</sup>F-GE-180 to evaluate microglial activation in liver-transplanted patients under different regimens of immunosuppression. PET was performed in 22 liver-transplanted patients (3 CNI free, 9 with low-dose CNI, 10 with standard-dose CNI immunosuppression) and 9 healthy controls. The total distribution volume (V<sub>T</sub>) estimated in 12 volumes-of-interest was analyzed regarding TSPO genotype, CNI therapy, and cognitive performance. In controls, V<sub>T</sub> was about 80% higher in high affinity binders (n = 5) compared to mixed affinity binders (n = 3). Mean V<sub>T</sub> corrected for TSPO genotype was significantly lower in patients compared to controls, especially in patients in whom CNI dose had been reduced because of nephrotoxic side effect. Our results provide evidence of chronic suppression of microglial activity in liver-transplanted patients under CNI therapy especially in patients with high sensitivity to CNI toxicity.
Medical subject headings
- Liver Transplantation
- Microglia