Swarm: A federated cloud framework for large-scale variant analysis.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 33979321.
- Also identified by DOI 10.1371/journal.pcbi.1008977 and PMC identifier 8143397.
- Licence recorded as CC0.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Genomic data analysis across multiple cloud platforms is an ongoing challenge, especially when large amounts of data are involved. Here, we present Swarm, a framework for federated computation that promotes minimal data motion and facilitates crosstalk between genomic datasets stored on various cloud platforms. We demonstrate its utility via common inquiries of genomic variants across BigQuery in the Google Cloud Platform (GCP), Athena in the Amazon Web Services (AWS), Apache Presto and MySQL. Compared to single-cloud platforms, the Swarm framework significantly reduced computational costs, run-time delays and risks of security breach and privacy violation.
Medical subject headings
- Cloud Computing
- Computational Biology
- Genomics