Putting the Microenvironment into the Immunotherapy Companion Diagnostic.

Moutafi, Myrto; Rimm, David L · Clin Cancer Res · 2021

editorial · Level V

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Abstract

A <i>post hoc</i> analysis in advanced gastric cancer showed stronger association of programmed cell death-ligand 1 (PD-L1) with immunotherapy efficacy measured by combined positive score (CPS) compared with tumor cells (TC%). This finding suggests expression in immune cells in the tumor microenvironment increases the value of the companion diagnostic test.<i>See related article by Lei et al., p. 3926</i>.

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