Ancestry matters: Building inclusivity into preclinical study design.

Zaaijer, Sophie; Capes-Davis, Amanda · Cell · 2021

basic_science · Level V

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Abstract

Human cell lines (CLs) are key assets for biomedicine but lack ancestral diversity. Here, we explore why genetic diversity among cell-based models is essential for making preclinical research more equitable and widely translatable. We lay out practical actions that can be taken to improve inclusivity in study design.

Medical subject headings