Reduced BNT162b2 Messenger RNA Vaccine Response in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Naive Nursing Home Residents.

Canaday, David H; Carias, Lenore; Oyebanji, Oladayo A; Keresztesy, Debbie; Wilk, Dennis; Payne, Michael; Aung, Htin; St Denis, Kerri et al. · Clin Infect Dis · 2021

prospective_cohort · Level II

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Abstract

After BNT162b2 messenger RNA vaccination, antibody levels to spike, receptor-binding domain, and virus neutralization were examined in 149 nursing home residents and 110 healthcare worker controls. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-naive nursing home residents' median post-second vaccine dose antibody neutralization titers are one-quarter that of SARS-CoV-2-naive healthcare workers.

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