The Panorama of Cancer Genetics.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 33999839.
- Also identified by DOI 10.1158/0008-5472.CAN-21-0885 and PMC identifier 8293694.
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Abstract
Cancer, a disease of the genome, is caused by a combination of germline predisposing variants and acquired somatic mutations. A unified view of heritable and acquired genetic factors will improve our understanding of cancer occurrence and progression. Fanfani and colleagues provide new insight into heritable cancer risk through a computational method that identifies genes and loci that contribute strongly to cancer heritability; many of these loci also harbor somatic drivers. Beyond improving cancer clinical outcomes, these methods will also be valuable across complex disorders by identifying regions responsible for missing heritability.<i>See related article by Fanfani et al., p. 2588</i>.
Medical subject headings
- Neoplasms