HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in <i>C. elegans</i>.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34003109.
- Also identified by DOI 10.7554/eLife.63299 and PMC identifier 8131101.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Eukaryotic cells use guided search to coordinately control dispersed genetic elements. Argonaute proteins and their small RNA cofactors engage nascent RNAs and chromatin-associated proteins to direct transcriptional silencing. The small ubiquitin-like modifier (SUMO) has been shown to promote the formation and maintenance of silent chromatin (called heterochromatin) in yeast, plants, and animals. Here, we show that Argonaute-directed transcriptional silencing in <i>Caenorhabditis elegans</i> requires SUMOylation of the type 1 histone deacetylase HDA-1. Our findings suggest how SUMOylation promotes the association of HDAC1 with chromatin remodeling factors and with a nuclear Argonaute to initiate de novo heterochromatin silencing.
Medical subject headings
- Argonaute Proteins
- Caenorhabditis elegans
- Histone Deacetylase 1
- Sumoylation
- Transcription, Genetic