Self-Adjuvant Effect by Manipulating the Bionano Interface of Liposome-Based Nanovaccines.
basic_science · Level V
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- Record sourced from PubMed, PMID 34010008.
- Also identified by DOI 10.1021/acs.nanolett.1c01133.
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Abstract
Nanovaccines are of increasing scrutiny due to their plasticity in size, composition, and surface properties to enhance antigenicity. However, inevitable absorption of plasma proteins affects the <i>in vivo</i> fate of nanovaccines by reshaping biological identity. Herein IgM was validated as a self-adjuvant by regulating antigen-presenting cells recognition of liposome-based nanovaccines. <sup>D</sup>CDX-modified liposomes with loading of ovalbumin (<sup>D</sup>CDX-sLip/OVA) heavily absorbed IgM <i>via</i> electrostatic interaction, demonstrating significant splenic B cells targeting. IgM absorbed on <sup>D</sup>CDX-sLip/OVA enhanced antigen uptake and presentation by both IgM-complement and IgM-FcμR pathways. <sup>D</sup>CDX-sLip/OVA induced a stronger IgG1 titer than ovalbumin-loaded plain liposomes (sLip/OVA) while maintaining a comparably high level of IgG2a titer with high biosafety, indicating that IgM absorption after <sup>D</sup>CDX modification could improve the antigenicity by enhancing the Th2-polarized immune response. The present work suggested manipulation of IgM absorption may provide a new impetus to improve <i>in vivo</i> performance of nanovaccines.
Medical subject headings
- Adjuvants, Immunologic
- Liposomes