Cerebral Amyloid Angiopathy-Related Transient Focal Neurologic Episodes.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 34016709.
- Also identified by DOI 10.1212/WNL.0000000000012234 and PMC identifier 8356377.
- Licence recorded as CC BY-NC-ND.
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Abstract
Transient focal neurologic episodes (TFNEs) are brief disturbances in motor, somatosensory, visual, or language functions that can occur in patients with cerebral amyloid angiopathy (CAA) and may be difficult to distinguish from TIAs or other transient neurologic syndromes. They herald a high rate of future lobar intracerebral hemorrhage, making it imperative to differentiate them from TIAs to avoid potentially dangerous use of antithrombotic drugs. Cortical spreading depression or depolarization triggered by acute or chronic superficial brain bleeding, a contributor to brain injury in other neurologic diseases, may be the underlying mechanism. This review discusses diagnosis, pathophysiology, and management of CAA-related TFNEs.
Medical subject headings
- Cerebral Amyloid Angiopathy
- Nervous System Diseases