Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34018656.
- Also identified by DOI 10.1111/acel.13357 and PMC identifier 8208793.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age-related differentially expressed genes from the GTEx RNA sequencing database of 54 tissue types from 979 human subjects and found significantly more upregulated than downregulated genes in subtelomeric regions as compared to the genome-wide average. Our data demonstrate spatial relationships between telomeres and gene expression in aging.
Medical subject headings
- Cellular Senescence
- Gene Expression
- Telomere