Phosphate meeting cholesterol-consequences for cardiovascular disease in chronic kidney disease?
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 34023025.
- Also identified by DOI 10.1016/j.kint.2021.02.022.
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Abstract
Cardiovascular disease is highly prevalent in patients with chronic kidney disease. Hyperphosphatemia is associated with subclinical atheromatosis in chronic kidney disease. Phosphate-induced endothelial dysfunction and vascular calcification are thought to be key inducers of atherosclerosis in this condition. Zhou et al. now demonstrate that phosphate promotes de novo cholesterol synthesis in vascular smooth muscle and macrophages through increased 3-hydroxy-3-methylglutaryl coenzyme A reductase activation. This observation may change current concepts of atherosclerosis development and management in chronic kidney disease.
Medical subject headings
- Atherosclerosis
- Cardiovascular Diseases
- Hyperphosphatemia
- Renal Insufficiency, Chronic
- Vascular Calcification