SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34027499.
- Also identified by DOI 10.1016/j.xcrm.2021.100286 and PMC identifier 8130189.
- Licence recorded as CC BY-NC-ND.
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Abstract
COVID-19 variants of concern, including B.1.1.7, B.1.351, and P.1, encompass mutations facilitating immune evasion. Neutralizing antibody recognition and function may be variably impaired. We considered the impact of mutations on T cell responses. Mutations could be neutral or result in either loss or gain of predicted epitopes depending on HLA type.
Medical subject headings
- Antibodies, Neutralizing
- SARS-CoV-2
- T-Lymphocytes