Intratumoral CXCR5<sup>+</sup>CD8<sup>+</sup>T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer.
Where this comes from
- Record sourced from PubMed, PMID 34035252.
- Also identified by DOI 10.1038/s41467-021-23356-w and PMC identifier 8149695.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Studies that examined an association between CD8<sup>+</sup>T and prognosis in gastric cancer are inconsistent, and a distinct population of CXCR5<sup>+</sup>CD8<sup>+</sup>T associated with better overall survival has been reported among various malignancies. Here, we show that the abundance of intratumoral CXCR5<sup>+</sup>CD8<sup>+</sup>T cells is associated with better overall survival in patients with gastric cancer. Patients with TNM II + III gastric cancer with higher intratumoral CXCR5<sup>+</sup>CD8<sup>+</sup>T cell infiltration are more likely to benefit from adjuvant chemotherapy. Microsatellite-unstable and Epstein-Barr virus positive tumors are enriched with CXCR5<sup>+</sup>CD8<sup>+</sup>T cells. Gastric cancer infiltrating CXCR5<sup>+</sup>CD8<sup>+</sup>T cells represent a specific subtype of stem-like CD8<sup>+</sup>T with effector memory feature. Identification of the clinical significance and phenotype of gastric cancer infiltrating CXCR5<sup>+</sup>CD8<sup>+</sup>T provides a roadmap for patient stratification and trials of targeted therapies.
Medical subject headings
- CD8-Positive T-Lymphocytes
- Lymphocytes, Tumor-Infiltrating
- Receptors, CXCR5
- Stomach Neoplasms