How elite controllers and posttreatment controllers inform our search for an HIV-1 cure.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 34060478.
- Also identified by DOI 10.1172/JCI149414 and PMC identifier 8159676.
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Abstract
A small percentage of people living with HIV-1 can control viral replication without antiretroviral therapy (ART). These patients are called elite controllers (ECs) if they are able to maintain viral suppression without initiating ART and posttreatment controllers (PTCs) if they control HIV replication after ART has been discontinued. Both types of controllers may serve as a model of a functional cure for HIV-1 but the mechanisms responsible for viral control have not been fully elucidated. In this review, we highlight key lessons that have been learned so far in the study of ECs and PTCs and their implications for HIV cure research.
Medical subject headings
- Anti-Retroviral Agents
- HIV Infections
- HIV-1