Brains and brawn: Stress-induced myokine abates nervous system aging.

Tsui, C Kimberly; Dishart, Julian G; Dillin, Andrew · Cell Metab · 2021

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Abstract

Skeletal muscle secretes numerous systemic factors, termed myokines, which can regulate homeostasis of distal tissues. In this issue, Rai et al. (2021) identify and characterize a novel myokine, Amyrel, which is secreted under muscle proteasome stress and protects central nervous system health and function by enhancing protein quality control during aging.

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