A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion.
Level V
Where this comes from
- Record sourced from PubMed, PMID 34077715.
- Also identified by DOI 10.1016/j.cmet.2021.05.004.
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Abstract
Akkermansia muciniphila is a gut commensal known to improve host metabolism. The outer membrane protein Amuc_1100 has been shown to partially replicate these beneficial effects. Here, Yoon et al. (2021) have identified a novel protein (P9) secreted by A. muciniphila that stimulates GLP-1 secretion, thereby adding new insight to the biomolecule era to treat metabolic diseases.
Medical subject headings
- Akkermansia
- Glucagon-Like Peptide 1
- Humans
- Membrane Proteins
- Metabolic Diseases
- Transcription Factors