Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 34079986.
- Also identified by DOI 10.1093/cid/ciab511 and PMC identifier 8906715.
- Licence recorded as CC BY-NC-ND.
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Abstract
We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.
Medical subject headings
- Enterobacter cloacae
- Siderophores