Structures and functions of the inflammasome engine.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 34092352.
- Also identified by DOI 10.1016/j.jaci.2021.04.018 and PMC identifier 8597577.
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Abstract
Inflammasomes are molecular machines that carry out inflammatory responses on challenges by pathogens and endogenous dangers. Dysregulation of inflammasome assembly and regulation is associated with numerous human diseases from autoimmunity to cancer. In recent years, significant advances have been made in understanding the mechanism of inflammasome signaling using structural approaches. Here, we review inflammasomes formed by the NLRP1, NLRP3, and NLRC4 sensors, which are well characterized structurally, and discuss the structural and functional diversity among them.
Medical subject headings
- Inflammasomes